眶额皮层功能障碍可区分行为变异型额颞叶痴呆与阿尔茨海默病。

Orbitofrontal dysfunction discriminates behavioral variant frontotemporal dementia from Alzheimer's disease.

机构信息

Neuroscience Research Australia, Barker & Easy Streets, Randwick, Sydney, NSW 2031, Australia.

出版信息

Dement Geriatr Cogn Disord. 2010;30(6):547-52. doi: 10.1159/000321670. Epub 2011 Jan 20.

DOI:10.1159/000321670

PMID:21252550

Abstract

BACKGROUND

Behavioral variant frontotemporal dementia (bvFTD) patients show prefrontal cortex dysfunction and atrophy.

METHODS

We investigated whether executive function in conjunction with prefrontal cortex atrophy discriminates bvFTD and Alzheimer's disease (AD) patients efficiently at presentation.

RESULTS

AD and bvFTD patients were distinguishable by 89.5% on their performance of 3 executive tasks: the Hayling Test of Inhibitory Control, Digit Span Backward and Letter Fluency. Similarly, scan ratings showed that orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling error score in conjunction with the OFC atrophy rating showed that 92% of patients can be correctly classified into bvFTD and AD.

CONCLUSION

A combination of OFC and disinhibition measures appears to be a powerful diagnostic tool in differentiating bvFTD from AD patients in this preliminary study.

摘要

背景

行为变异额颞叶痴呆（bvFTD）患者表现出前额叶皮层功能障碍和萎缩。

方法

我们研究了执行功能联合前额叶皮层萎缩是否能在发病时有效地鉴别 bvFTD 和阿尔茨海默病（AD）患者。

结果

AD 和 bvFTD 患者在 3 项执行任务中的表现可以区分，分别为：Hayling 抑制控制测试、数字倒背和字母流畅性测试。同样，扫描评分显示眶额皮层（OFC）和背外侧前额叶皮层区域可以区分这两个患者群体。更重要的是，采用 Hayling 错误评分与 OFC 萎缩评分相结合，可以将 92%的患者正确分类为 bvFTD 和 AD。