Cell Cycle and Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Essays Biochem. 2012;53:141-68. doi: 10.1042/bse0530141.
The Scribble, Par and Crumbs modules were originally identified in the vinegar (fruit) fly, Drosophila melanogaster, as being critical regulators of apico-basal cell polarity. In the present chapter we focus on the Scribble polarity module, composed of Scribble, discs large and lethal giant larvae. Since the discovery of the role of the Scribble polarity module in apico-basal cell polarity, these proteins have also been recognized as having important roles in other forms of polarity, as well as regulation of the actin cytoskeleton, cell signalling and vesicular trafficking. In addition to these physiological roles, an important role for polarity proteins in cancer progression has also been uncovered, with loss of polarity and tissue architecture being strongly correlated with metastatic disease.
Scribble、Par 和 Crumbs 模块最初在醋（果）蝇 Drosophila melanogaster 中被鉴定为顶端-基底细胞极性的关键调节因子。在本章中，我们重点介绍 Scribble 极性模块，该模块由 Scribble、Discs large 和 lethal giant larvae 组成。自发现 Scribble 极性模块在顶端-基底细胞极性中的作用以来，这些蛋白质也被认为在其他形式的极性以及肌动蛋白细胞骨架、细胞信号和囊泡运输的调节中具有重要作用。除了这些生理作用外，极性蛋白在癌症进展中的重要作用也被揭示出来，极性和组织架构的丧失与转移性疾病密切相关。
