Department of Cell Biology, G-COE, Kobe University Graduate School of Medicine, Chuo-ku, Japan.
J Genet Genomics. 2011 Oct 20;38(10):461-70. doi: 10.1016/j.jgg.2011.09.005. Epub 2011 Sep 17.
Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression. scribble/discs large/lethal giant larvae (scrib/dlg/lgl), a group of apico-basal polarity genes, were initially identified as members of "neoplastic" tumor-suppressors in flies. The components of the Hippo signaling pathway, which is crucial for organ size control and cancer development, were also identified through Drosophila genetic screens as members of "hyperplastic" tumor-suppressors. Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors. The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton, cell-cell contact, and apical-domain size of the epithelial cell.
顶端-基底极性的丧失是驱动上皮肿瘤进展的关键因素之一。scribble/discs large/lethal giant larvae（scrib/dlg/lgl），一组顶端-基底极性基因，最初被鉴定为果蝇中“致癌”肿瘤抑制因子的成员。Hippo 信号通路的组成部分对于器官大小控制和癌症发展至关重要，也通过果蝇遗传筛选被鉴定为“增生性”肿瘤抑制因子的成员。最近的研究积累的证据表明，这两个肿瘤抑制信号通路不是相互排斥的，而是协同作用产生高度恶性的肿瘤。这些肿瘤抑制途径的相互作用可能包括肌动蛋白细胞骨架、细胞-细胞接触和上皮细胞顶端区域大小的失调。
