Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Cornea. 2013 May;32(5):615-8. doi: 10.1097/ICO.0b013e318259c970.
To evaluate detailed morphologic changes of Terrien marginal degeneration (TMD) using anterior segment optical coherence tomography (AS-OCT).
Two patients with TMD were examined by 1310-nm wavelength swept source optical coherence tomography, corneal topography, and slit-lamp microscopy.
AS-OCT depicted corneal thinning with intact epithelial layer in the peripheral cornea of both patients. Moreover, AS-OCT images of both patients clearly showed cavity formation surrounded and enclosed by intact epithelial and endothelial layers in the thinned area.
We demonstrate here the existence of cavity formation in the peripheral cornea with TMD. This observation suggests a possibility that corneal thinning in TMD is associated with cavity formation in the corneal stroma. AS-OCT is useful for the observation of detailed morphologic changes of diseased cornea.
使用眼前节光学相干断层扫描（AS-OCT）评估边缘性角膜变性（TMD）的详细形态变化。
对 2 例 TMD 患者进行 1310nm 波长扫频源光学相干断层扫描、角膜地形图和裂隙灯显微镜检查。
AS-OCT 显示 2 例患者的周边角膜均有角膜变薄，上皮层完整。此外，2 例患者的 AS-OCT 图像均清晰显示在变薄区域，存在由完整的上皮和内皮层包围和封闭的腔形成。
我们在此证明 TMD 周边角膜存在腔形成。这一观察结果提示 TMD 中的角膜变薄可能与角膜基质中的腔形成有关。AS-OCT 可用于观察病变角膜的详细形态变化。
