HDR Research Center, Hoopes Vision, Draper, UT, United States.
John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, United States.
Surv Ophthalmol. 2019 Mar-Apr;64(2):162-174. doi: 10.1016/j.survophthal.2018.09.004. Epub 2018 Oct 12.
Terrien marginal degeneration, a rare disease resulting in peripheral corneal thinning, commonly occurs in middle-aged males and usually manifests clinically with decreased visual acuity from increased corneal astigmatism. Although the exact etiology is unknown, hypotheses focus on possible degenerative and inflammatory origins. Histopathologic studies often reveal characteristic findings of innumerable intracellular and extracellular vacuoles in the affected stroma. Distinguishing Terrien marginal degeneration from other peripheral corneal diseases such as Mooren ulcer and pellucid marginal degeneration is important. Nonsurgical interventions include spectacles, rigid gas-permeable contact lenses, and scleral lenses; however, when the corneal thickness is ≤150 μm, surgical interventions including tectonic grafting and lamellar keratoplasty may be necessary.
边缘性角膜变性，一种导致周边角膜变薄的罕见疾病，常见于中年男性，通常表现为因角膜散光而导致的视力下降。虽然确切病因尚不清楚，但假说主要集中在可能的退行性和炎症性起源上。组织病理学研究常显示出受影响基质中无数细胞内和细胞外空泡的特征性发现。将边缘性角膜变性与其他周边角膜疾病（如莫伦溃疡和角膜边缘透明变性）区分开来很重要。非手术干预包括眼镜、硬性透气性角膜接触镜和巩膜镜；然而，当角膜厚度≤150μm 时，可能需要手术干预，包括板层角膜移植和组织移植。
