Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.
Am J Med Sci. 2012 Sep;344(3):245-7. doi: 10.1097/MAJ.0b013e318254bd71.
Renal glycosuria is defined as the excretion of glucose in urine in a normoglycemic state. It results from renal tubular dysfunction or immaturity of tubular function in the newborn. Etiologically, renal glycosuria is of 3 types-benign renal glycosuria, glycosuria with diabetes mellitus (including gestational diabetes) and tubular defects (Fanconi syndrome). Prognosis of benign renal glycosuria is excellent and reversible. Acute interstitial nephritis (AIN) is one of the main causes of acute renal failure and may often result in tubular dysfunction. In this study, the authors report the occurrence of AIN with acute renal failure that contributed to reversible renal glycosuria. The glycosuria observed in the patient of this study was an isolated tubular defect, with no phosphaturia, aminoaciduria or bicarbonaturia. Such a presentation is very rare in adults and has not been previously reported. These findings confirm that AIN with acute renal failure can cause an isolated tubular defect with benign reversible glycosuria in an adult.
肾性糖尿定义为在血糖正常的情况下尿中出现葡萄糖。它是由肾小管功能障碍或新生儿肾小管功能不成熟引起的。从病因学上讲，肾性糖尿分为 3 种类型——良性肾性糖尿、伴糖尿病（包括妊娠期糖尿病）的糖尿和管状缺陷（范可尼综合征）。良性肾性糖尿的预后极好且是可逆的。急性间质性肾炎（AIN）是急性肾衰竭的主要原因之一，常可导致肾小管功能障碍。在本研究中，作者报告了急性肾衰竭伴 AIN 导致可逆性肾性糖尿的发生。本研究中患者观察到的糖尿是孤立的管状缺陷，无磷尿、氨基酸尿或碳酸氢盐尿。这种表现形式在成人中非常罕见，以前也没有报道过。这些发现证实急性肾衰竭伴 AIN 可导致成人出现孤立的管状缺陷和良性可逆性糖尿。
