Louwen Frank, Muschol-Steinmetz Cornelia, Reinhard Joscha, Reitter Anke, Yuan Juping
Department of Gynecology and Obstetrics, School of Medicine, J W Goethe-University, Frankfurt, Germany.
Oncotarget. 2012 Aug;3(8):759-73. doi: 10.18632/oncotarget.595.
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated. Its deregulation has been implicated in preeclampsia, a leading cause for maternal and perinatal mortality and morbidity. Pathogenesis of preeclampsia remains to be defined. Microarray-based gene profiling has been widely used for identifying genes responsible for preeclampsia. In this review, we have summarized the recent data from the microarray studies with preeclamptic placentas. Despite the complex of gene signatures, suggestive of the heterogeneity of preeclampsia, these studies identified a number of differentially expressed genes associated with preeclampsia. Interestingly, most of them have been reported to be tightly involved in tumor progression. We have discussed these interesting genes and analyzed their potential molecular functions in preeclampsia, compared with their roles in malignancy development. Further investigations are warranted to explore the involvement in molecular network of each identified gene, which may provide not only novel strategies for prevention and therapy for preeclampsia but also a better understanding of cancer cells. The trophoblastic cells, with their capacity for proliferation and differentiation, apoptosis and survival, migration, angiogenesis and immune modulation by exploiting similar molecular pathways, make them a compelling model for cancer research.
肿瘤进展与妊娠有许多共同特征，如免疫耐受和侵袭。胎盘滋养层细胞侵入子宫壁对胎儿发育至关重要，因此受到精确调控。其调控失常与子痫前期有关，子痫前期是孕产妇和围产期发病和死亡的主要原因。子痫前期的发病机制仍有待明确。基于微阵列的基因谱分析已被广泛用于鉴定子痫前期相关基因。在本综述中，我们总结了来自子痫前期胎盘微阵列研究的最新数据。尽管基因特征复杂，提示子痫前期具有异质性，但这些研究确定了一些与子痫前期相关的差异表达基因。有趣的是，其中大多数基因已被报道与肿瘤进展密切相关。我们讨论了这些有趣的基因，并分析了它们在子痫前期中的潜在分子功能，并与它们在恶性肿瘤发展中的作用进行了比较。有必要进一步研究每个已鉴定基因在分子网络中的作用，这不仅可能为子痫前期的预防和治疗提供新策略，还能更好地理解癌细胞。滋养层细胞具有增殖、分化、凋亡、存活、迁移、血管生成和免疫调节能力，通过利用相似的分子途径，使其成为癌症研究的一个有吸引力的模型。
