Schlitt M, Bucher A P, Quindlen E A, Jennings R, Bastian F O
Department of Neurosurgery, University of South Alabama Medical Center.
Med Hypotheses. 1990 Nov;33(3):177-9. doi: 10.1016/0306-9877(90)90172-b.
Although mesial temporal sclerosis has been recognized for more than 100 years, its etiology remains unknown. It is proposed that a common infectious agent, herpes simplex virus type-1, may cause this disorder by means of a nonfulminant infection of mesial temporal lobe structures, which is resolved by the immune system and becomes gliotic in the course of healing by the central nervous system. Brain sections from a long-term experiment in a model of herpes simplex encephalitis reveal such a scar, which shows a high concentration of glial fibrillary acidic protein, without any evidence of residual herpes antigen, by immunocytochemistry.
尽管内侧颞叶硬化已被认识超过100年，但其病因仍然不明。有人提出，一种常见的感染因子——1型单纯疱疹病毒，可能通过对内侧颞叶结构的非暴发性感染导致这种疾病，这种感染可被免疫系统清除，并在中枢神经系统愈合过程中发生胶质化。在单纯疱疹性脑炎模型的长期实验中获得的脑切片显示出这样一个瘢痕，通过免疫细胞化学检测，该瘢痕显示胶质纤维酸性蛋白浓度很高，且没有任何残留疱疹抗原的证据
