Williams A D
Med Hypotheses. 1990 Nov;33(3):213-7. doi: 10.1016/0306-9877(90)90179-i.
Hyperlipidaemia has become generally accepted as a cause of coronary artery atherosclerosis, arterial occlusion and subsequent myocardial infarction. This may be true in a few people with lipid intolerance, but for the majority, hyperlipidaemia represents a normal physiological response to another pathological process. One such disease process involves the vessel wall, which appears to suffer injury. The cause of the injury may be associated with abnormal movement in the wall and this in turn can be provoked by stress. A hypothesis encompassing these observations is proposed. It would therefore appear that hyperlipidaemia is not a cause of arterial disease, but as part of normal homeostasis, it can be a risk indicator. It is dangerous to consider hyperlipidaemia as a cause of myocardial infarction as this leads to inappropriate treatment. The lowering of cholesterol and low density lipoproteins (LDL) by any means other than sensible dieting may be likened to attempts to lower elevated white blood cell counts in cases of bacterial pneumonia, without treating the pneumonia.
高脂血症已被普遍认为是冠状动脉粥样硬化、动脉阻塞及随后心肌梗死的一个病因。在少数脂质不耐受的人身上可能确实如此，但对大多数人来说，高脂血症是对另一种病理过程的正常生理反应。一种这样的疾病过程涉及血管壁，血管壁似乎受到了损伤。损伤的原因可能与血管壁内的异常运动有关，而这反过来又可能由压力引发。提出了一个包含这些观察结果的假说。因此，似乎高脂血症不是动脉疾病的病因，而是作为正常内稳态的一部分，它可能是一个风险指标。将高脂血症视为心肌梗死的病因是危险的，因为这会导致不恰当的治疗。通过合理饮食以外的任何方式降低胆固醇和低密度脂蛋白（LDL），可能类似于在细菌性肺炎病例中不治疗肺炎而试图降低升高的白细胞计数。
