Velaskar D S, Chitre A P
Angiology. 1986 Apr;37(4):306-13. doi: 10.1177/000331978603700407.
Hyperlipidaemia and platelet hyperfunction have been considered as high-risk factors for atherogenesis. Simultaneous study of these two parameters was undertaken in 43 patients with atherosclerosis (as evidenced by frank myocardial infarction, MI, in 23 patients and ischemic heart disease, IHD, in 20 patients); and in 36 normal subjects who were matched for age (45 to 60 years). Incidence of either of these parameters being high was 36% in normals, 85% in atherosclerosis. Four subjects with circulating platelet aggregates and hyperlipidaemia showed progression of the lesion by crossing over the category of normal to IHD (two) and from IHD to MI (two). These two risk factors, together or independently, appear to cause and control the progress of atherosclerosis and their simultaneous study can be used for its diagnosis. A concept of subintimal hyperlipidosis is presented since none of the existing theories can explain the existence of atherosclerotic lesions exclusively on the developed vascular musculature.
高脂血症和血小板功能亢进被认为是动脉粥样硬化形成的高危因素。对43例动脉粥样硬化患者（其中23例有明确的心肌梗死，20例有缺血性心脏病）以及36例年龄匹配（45至60岁）的正常受试者同时进行了这两个参数的研究。这些参数中任何一个偏高的发生率在正常受试者中为36%，在动脉粥样硬化患者中为85%。4例有循环血小板聚集和高脂血症的受试者出现病变进展，从正常类别转变为缺血性心脏病（2例），以及从缺血性心脏病转变为心肌梗死（2例）。这两个危险因素，共同或单独作用，似乎会引发并控制动脉粥样硬化的进展，同时研究它们可用于动脉粥样硬化的诊断。由于现有的理论均无法仅依据已发育的血管肌肉组织来解释动脉粥样硬化病变的存在，因此提出了内膜下高脂血症的概念。
