Perova N V, Chernysheva N P, Shcherbakova I A, Polesskiĭ V A
Kardiologiia. 1979 Dec;19(12):66-71.
The content in the blood plasma of the main apolipoproteins of lipoproteins of very low and low density apo-B and tetramethylurea-soluble apo-LP as well as lipoproteins of high density apo-A and the relation to apo-LP cholesterol of these classes of lipoproteins were studied in 34 males with different levels of alpha-LP cholesterol. It is shown that in hypoalphacholesterolemia the plasma apo-A content is reduced with the cholesterol/apo-A ratio being less than in normoalphacholesterolemia; at the same time, the content in the plasma of total triglycerides, cholesterol, and protein of very low density lipoproteins is increased and cholesterol saturation calculated for protein of very low and low density lipoproteins does not change. In hyperalphacholesterolemia the plasma apo-A content is increased both in the absolute amount and in relation to apo-B and TMU-soluble proteins; the content of cholesterol on apo-A in high density lipoproteins is the same as under normal conditions and higher than in hypoalphacholesterolemia. The results obtained are discussed in association with the data in the literature concerning the functions of lipoproteins and apo-LP in relation to the transport of cholesterol into the vascular wall and its drainage.
对34名具有不同α-LP胆固醇水平的男性，研究了极低密度脂蛋白和低密度脂蛋白的主要载脂蛋白apo-B以及四甲基脲可溶性apo-LP的血浆含量，以及高密度脂蛋白apo-A及其与这些类型脂蛋白的apo-LP胆固醇的关系。结果表明，在低α胆固醇血症中，血浆apo-A含量降低，胆固醇/apo-A比值低于正常α胆固醇血症；同时，极低密度脂蛋白的血浆总甘油三酯、胆固醇和蛋白质含量增加，极低密度和低密度脂蛋白蛋白质的胆固醇饱和度不变。在高α胆固醇血症中，血浆apo-A含量的绝对值以及相对于apo-B和四甲基脲可溶性蛋白质均增加；高密度脂蛋白中apo-A上的胆固醇含量与正常条件下相同，且高于低α胆固醇血症。结合文献中有关脂蛋白和apo-LP在胆固醇向血管壁转运及其清除方面功能的数据，对所得结果进行了讨论。
