Vecera R, Chmela Z, Hrebícek J, Skottová N
Institute of Medical Chemistry, Medical Faculty of Palacký University, Olomouc, Czech Republic.
Acta Univ Palacki Olomuc Fac Med. 1994;137:35-8.
Proportions of unsaturated fatty acids of high density lipoprotein (HDL) lipids and their relationships to the HDL-cholesterol level were compared in hypo- and hyperalphalipoproteinemic subjects. Both groups did not differ in the level of serum cholesterol. However, hypoalphalipoproteinemia was associated with hypertriglyceridemia, higher HDL-triacylglycerol level, and higher proportion of HDL-18:1 (oleic acid) and lower proportions of HDL-18:2 (linoleic acid) and 20:4 (arachidonic acid) than hyperalphalipoproteinemia. The HDL-20:4 was the only fatty acid correlating (negatively) with HDL-cholesterol. However, HDL-18:1 correlated positively and HDL-18:2 negatively with HDL-triacylglycerols, lipids related to the fall of HDL-cholesterol. These results suggest 1) an antagonism of 20:4 and 18:2 as structural components of HDL lipids in relation to the HDL-cholesterol level, and 2) an association of replacement of HDL 18:2 by 18:1 with the disorder of plasma triacylglycerol metabolism.
对低脂蛋白血症和高脂蛋白血症患者高密度脂蛋白（HDL）脂质中不饱和脂肪酸的比例及其与HDL胆固醇水平的关系进行了比较。两组患者的血清胆固醇水平无差异。然而，低脂蛋白血症与高甘油三酯血症、较高的HDL-三酰甘油水平相关，与高脂蛋白血症相比，HDL-18:1（油酸）比例更高，而HDL-18:2（亚油酸）和20:4（花生四烯酸）比例更低。HDL-20:4是唯一与HDL胆固醇呈负相关的脂肪酸。然而，HDL-18:1与HDL-三酰甘油呈正相关，HDL-18:2与HDL-三酰甘油呈负相关，HDL-三酰甘油与HDL胆固醇的降低有关。这些结果表明：1）20:4和18:2作为HDL脂质的结构成分，在HDL胆固醇水平方面存在拮抗作用；2）HDL 18:2被18:1取代与血浆三酰甘油代谢紊乱有关。
