Harms L, Hiepe F
Klinik und Hochschulambulanz für Neurologie, Charité Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Deutschland.
Z Rheumatol. 2012 Sep;71(7):564-71. doi: 10.1007/s00393-012-0958-z.
In connective tissue diseases, especially systemic lupus erythematosus and Sjögren's syndrome, diverse neurological symptoms and syndromes involving both the central and peripheral nervous system can occur at any stage of the disease. The pathogenesis is diverse. Prevalence figures in the literature vary considerably and the causal relationships are often uncertain. Very often connective tissue diseases must be considered in the differential diagnosis of conditions manifesting with unclear neurological symptoms. Both rheumatologists and neurologists should be familiar with the main neurological signs, symptoms and complications of connective tissue diseases and should recognize the importance of diagnostic testing.
在结缔组织病中，尤其是系统性红斑狼疮和干燥综合征，在疾病的任何阶段都可能出现涉及中枢和周围神经系统的多种神经症状和综合征。其发病机制多种多样。文献中的患病率数据差异很大，因果关系往往也不明确。在对神经症状不明确的疾病进行鉴别诊断时，常常必须考虑结缔组织病。风湿病学家和神经科医生都应该熟悉结缔组织病的主要神经体征、症状和并发症，并应认识到诊断性检查的重要性。
