Ohnishi K, Uchiyama-Nakamura F
Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Sumida City, Tokyo 130-8575, Japan.
Int J STD AIDS. 2012 Aug;23(8):e1-3. doi: 10.1258/ijsa.2009.009264.
Metronidazole is the drug of choice for invasive amoebiasis; however, it is not known whether its dose or duration require modification in HIV infection when treating invasive amoebiasis. Seven HIV-positive patients with acute phase amoebic liver abscess were treated with daily oral administration of 1500 mg of metronidazole for 10 days. None of the patients required abscess drainage, and metronidazole was effective in all patients without serious side-effects. The CD4 cell count or HIV viral load did not appear to influence the efficacy of metronidazole therapy.
甲硝唑是侵袭性阿米巴病的首选药物；然而，在治疗侵袭性阿米巴病时，对于合并HIV感染的患者，其剂量或疗程是否需要调整尚不清楚。7例急性期阿米巴肝脓肿的HIV阳性患者接受了每日口服1500mg甲硝唑，疗程为10天的治疗。所有患者均无需进行脓肿引流，甲硝唑对所有患者均有效，且无严重副作用。CD4细胞计数或HIV病毒载量似乎不影响甲硝唑治疗的疗效。
