Mikami Y, Yu S F, Yazawa K, Fukushima K, Maeda A, Uno J, Terao K, Saito N, Kubo A, Suzuki K
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Mycopathologia. 1990 Nov;112(2):113-8. doi: 10.1007/BF00436506.
During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.
在我们对临床分离的诺卡氏菌产生的有毒物质进行研究期间，从皮肤诺卡氏菌病中鉴定出一种新的分离株，即耳炎诺卡氏菌，发现它能产生一种名为HS-6的有毒物质，该物质在体外和体内均具有很强的毒性。小鼠腹腔注射的半数致死量（LD50）值为1.25毫克/千克，L1210培养细胞的半数有效量（ED50）值为0.3纳克/毫升。HS-6的结构已确定，发现它属于16元大环类，分子式为C43H68O12。HS-6对新型隐球菌等致病真菌也有活性。
