Gilbert K A, Lydic R
Department of Anesthesia, Pennsylvania State University, College of Medicine, Hershey 17033.
Neurosci Lett. 1990 Dec 11;120(2):241-4. doi: 10.1016/0304-3940(90)90049-f.
Pontine parabrachial neurons have been suggested to play a regulatory role in both respiratory and sleep cycle control. Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observed during rapid eye movement (REM) sleep (Neurosci. Lett., 102 (1989) 211-216), this study tested the hypothesis that cholinergic mechanisms in the mPRF can also cause state-dependent changes in the discharge of parabrachial neurons. This paper describes extracellular recordings of parabrachial neurons during REM sleep and during the carbachol-induced REM sleep-like state (DCarb). Cells which were activated (REM-on) or inactivated (REM-off) during REM maintained the same state-dependent firing patterns during the DCarb state. These results support the hypothesis that cholinergic mechanisms in the mPRF can cause state-dependent changes in the discharge of parabrachial neurons.
脑桥臂旁神经元被认为在呼吸和睡眠周期控制中发挥调节作用。鉴于向猫的脑桥内侧网状结构（mPRF）微量注射胆碱能激动剂卡巴胆碱会产生与快速眼动（REM）睡眠期间观察到的呼吸变化相似的现象（《神经科学快报》，102 (1989) 211 - 216），本研究检验了mPRF中的胆碱能机制也可导致臂旁神经元放电出现状态依赖性变化这一假设。本文描述了在REM睡眠期间以及卡巴胆碱诱导的类REM睡眠状态（DCarb）下对臂旁神经元的细胞外记录。在REM期间被激活（REM - on）或失活（REM - off）的细胞在DCarb状态下保持相同的状态依赖性放电模式。这些结果支持了mPRF中的胆碱能机制可导致臂旁神经元放电出现状态依赖性变化这一假设。
