Williams M C
Department of Pathology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
Onderstepoort J Vet Res. 1990 Dec;57(4):263-8.
Poisoning with the plant Lasiospermum bipinnatum was studied in 9 lambs at various dose levels. Dyspnoea and tachypnoea, which were dose-related, were observed in 4 of the lambs. Gross and microscopic pulmonary lesions were found in all the lambs receiving plant material originating from one source but not in those given plant from another locality. The severity of the lesions appeared to be dose-dependent. Macroscopic lesions included pulmonary and mediastinal emphysema, congestion and oedema. Microscopically Clara cell hypertrophy and hyperplasia, and interstitial pneumonia were the most outstanding findings. It is speculated that the pulmonary lesions were induced by a furanosesquiterpene or tryptophan or a combination of both of these toxins in the dosed plant material. Miscellaneous and inconsistent lesions observed in the experimental animals included widespread haemorrhage (1 lamb), transudations into the body cavities and adrenocortical hyperplasia.
在9只羔羊身上研究了不同剂量水平的双羽糙苏中毒情况。4只羔羊出现了与剂量相关的呼吸困难和呼吸急促。在所有接受来自一个来源的植物材料的羔羊中发现了大体和显微镜下的肺部病变，但在给予来自另一个地方的植物的羔羊中未发现。病变的严重程度似乎与剂量有关。大体病变包括肺和纵隔气肿、充血和水肿。显微镜下最突出的发现是克拉拉细胞肥大和增生以及间质性肺炎。据推测，肺部病变是由给药植物材料中的呋喃倍半萜或色氨酸或这两种毒素的组合引起的。在实验动物中观察到的其他不一致的病变包括广泛出血（1只羔羊）、体腔渗出和肾上腺皮质增生。
