Gamma Knife of Spokane, 910 W 5th Ave, Suite 102, Spokane, WA, 99204, USA.
World J Surg Oncol. 2012 Aug 29;10:176. doi: 10.1186/1477-7819-10-176.
Melanoma and renal cell carcinoma have a well-documented tendency to develop metastases to the brain. Treating these lesions has traditionally been problematic, because chemotherapy has difficulty crossing the blood brain barrier and whole brain radiation therapy (WBRT) is a relatively ineffective treatment against these radioresistant tumor histologies. In recent years, stereotactic radiosurgery (SRS) has emerged as an effective and minimally-invasive treatment modality for irradiating either single or multiple intracranial structures in one clinical treatment setting. For this reason, we conducted a review of modern literature analyzing the efficacy of SRS in the management of patients with melanoma and renal cell carcinoma brain metastases. In our analysis we found SRS to be a safe, effective and attractive treatment modality for managing radioresistant brain metastases and highlighted the need for randomized trials comparing WBRT alone vs. SRS alone vs. WBRT plus SRS in treating patients with radioresistant brain metastases.
黑色素瘤和肾细胞癌有明确的向脑部转移的倾向。传统上，治疗这些病变一直存在问题，因为化疗很难穿过血脑屏障，而全脑放射治疗（WBRT）对这些抗辐射肿瘤组织学的治疗效果相对较差。近年来，立体定向放射外科（SRS）已成为一种有效且微创的治疗方式，可在一次临床治疗中辐照单个或多个颅内结构。基于此，我们对现代文献进行了回顾，分析了 SRS 在治疗黑色素瘤和肾细胞癌脑转移患者中的疗效。在我们的分析中，我们发现 SRS 是一种安全、有效且有吸引力的治疗方法，可用于治疗抗辐射性脑转移，并且强调了需要进行随机试验，比较单独 WBRT 与单独 SRS 与 WBRT 加 SRS 治疗抗辐射性脑转移患者的疗效。
