Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Okazaki, Japan.
Otol Neurotol. 2012 Oct;33(8):1452-7. doi: 10.1097/MAO.0b013e318268d54d.
Bell's palsy is highly associated with diabetes mellitus.
The cause of Bell's palsy in diabetes mellitus is not completely understood. Diabetic mononeuropathy or reactivation of herpes simplex virus type 1 (HSV-1) may be responsible for the facial paralysis seen in diabetic patients. We previously reported transient and ipsilateral facial paralysis in mice inoculated with HSV-1. In this study, we examined the neuropathogenesis of HSV-1 in diabetic mice to clarify the relationship between Bell's palsy and diabetes mellitus.
We compared the incidence and course of facial paralysis after HSV-1 inoculation in diabetic and nondiabetic mice groups. Diabetic mice were prepared by intraperitoneal streptozotocin injection. Facial nerve damage was assessed by electrophysiologic and histopathologic examinations.
Compared with the nondiabetic group, the incidence of facial nerve paralysis was significantly increased in the diabetic mice. Electrophysiologic examinations and histopathologic changes also revealed that the facial nerve damage was more severe in the diabetic group.
The aggravated course of HSV-1 infection in diabetes suggests that HSV-1 may be the main causative factor for the increased incidence of facial paralysis in diabetic patients.
贝尔氏麻痹与糖尿病高度相关。
糖尿病患者贝尔氏麻痹的病因尚未完全阐明。糖尿病单神经病或单纯疱疹病毒 1 型（HSV-1）的再激活可能导致糖尿病患者出现面瘫。我们之前曾报道过单纯疱疹病毒 1 型接种的小鼠出现短暂的同侧性面瘫。在这项研究中，我们研究了糖尿病小鼠中 HSV-1 的神经病理学发病机制，以阐明贝尔氏麻痹与糖尿病之间的关系。
我们比较了 HSV-1 接种后糖尿病和非糖尿病小鼠组面瘫的发生率和病程。通过腹腔内链脲佐菌素注射制备糖尿病小鼠。通过电生理和组织病理学检查评估面神经损伤。
与非糖尿病组相比，糖尿病小鼠面神经麻痹的发生率显著增加。电生理检查和组织病理学变化也表明，糖尿病组的面神经损伤更严重。
糖尿病中 HSV-1 感染过程的加重表明 HSV-1 可能是糖尿病患者面瘫发病率增加的主要致病因素。
