Jiang Guang-yu, Wei Shu-jiao, Li Xiao-ping, Wang Li-heng, Mai Zhi-dan, Ge Xian-min
The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Aug;30(8):561-6.
To explore the characters of lung injury induced by tin dusts and to provide the diagnosis evidence of tin pneumoconiosis.
Forty SD rats were randomly divided into four groups: the group exposed to tin dusts from smelting workshop, the group exposed to tin dusts from tin refining workshop, the positive control group exposed to standard quartz dusts and the negative control group exposed to saline. The pathological changes of rat lungs were observed dynamically.
In rats exposed to tin dusts, on the 30th day after exposure to tin dusts, the scattered hoar tip size of the spots in surface and section of the lungs were observed, the scattered focal granulomatous inflammation around the small bronchi and dust particles in lung tissue were observed under microscope; on the 90th day after exposure to tin dusts, the granulomatous inflammation increase, the fibroblasts proliferation, collagen fibers formation and positive VG staining were found. There were significant differences, as compared with positive or negative controls (P < 0.05). These pathological changes were basically the characters of specific pathological changes in early tin pneumoconiosis.
Non-ferrous metal tin dusts can induce the specific lung injury (granuloma formation) in lung tissue of rats exposed to tin dusts, which fulfilled the diagnostic criteria of specific pathological changes in early tin pneumoconiosis.
探讨锡尘所致肺损伤特点，为锡尘肺诊断提供依据。
40只SD大鼠随机分为4组：冶炼车间锡尘暴露组、精炼车间锡尘暴露组、标准石英尘阳性对照组、生理盐水阴性对照组。动态观察大鼠肺组织病理变化。
锡尘暴露大鼠，在暴露30天时，肉眼见肺表面及切面散在灰白色小结节，镜下见小支气管周围散在灶性肉芽肿性炎症及肺组织内粉尘颗粒；暴露90天时，肉芽肿性炎症增多，可见成纤维细胞增生、胶原纤维形成及VG染色阳性。与阳性或阴性对照组比较，差异有统计学意义（P<0.05）。这些病理变化基本符合早期锡尘肺特异性病理改变特点。
有色金属锡尘可致锡尘暴露大鼠肺组织发生特异性肺损伤（肉芽肿形成），符合早期锡尘肺特异性病理改变诊断标准。
