Bi Ying, Mao Ling, Wang Bin-sen, Shi Jin, Zhou Shao-wei, Chen Zi-dan, Bian Lu-qin, Zhang Yue
Department of pneumoconiosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Apr;30(4):265-7.
To explore the role of transbronchial lung biopsy (TBLB) in pathologic diagnosis of pneumoconiosis.
In our hospital during May 2011 and Sep 2011, the TBLB samples from 35 cases occupationally exposed to dusts were compared with the video-assisted thoracoscopic surgery or lobectomy samples from 27 cases not exposed to dusts for pathological indexes, including fibrotic proliferation, nodule or nodule-like, dust deposition and needle-shaped birefringent particles.
In group exposed to dusts, there were 6 cases (17.1%) with the moderate dust deposition and 28 cases (80.0%) with fibrotic proliferation. But in group not exposed to dusts, there were 0 case with the moderate dust deposition and 11 cases (40.0%) with fibrotic proliferation. There were significant differences between two groups (P < 0.05). In group exposed to dusts, there were 6 cases (17.1%) with Nodules-like and needle-shaped birefringent particles, but in group not exposed to dusts, there was 0 case with Nodules-like and needle-shaped birefringent particles.
TBLB could provide the evidence of pathological changes in lung tissue induced by dusts, and TBLB play an important role in pneumoconiosis diagnosis.
探讨经支气管肺活检（TBLB）在尘肺病病理诊断中的作用。
选取2011年5月至2011年9月在我院就诊的35例职业性接触粉尘患者的TBLB样本，与27例未接触粉尘患者的电视辅助胸腔镜手术或肺叶切除样本进行比较，观察纤维化增生、结节或结节样病变、粉尘沉积及针状双折射颗粒等病理指标。
接触粉尘组中，中度粉尘沉积6例（17.1%），纤维化增生28例（80.0%）；未接触粉尘组中，中度粉尘沉积0例，纤维化增生11例（40.0%）。两组比较差异有统计学意义（P < 0.05）。接触粉尘组中，有6例（17.1%）出现结节样病变及针状双折射颗粒，未接触粉尘组中无结节样病变及针状双折射颗粒。
TBLB可为粉尘致肺组织病理改变提供依据，在尘肺病诊断中发挥重要作用。
