Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.
Chin Med J (Engl). 2012 Aug;125(15):2790-3.
Intracranial germinomas are malignant neoplasms of gonadal origin, which have some features in terms of age, sex, and clinical manifestations. They mainly occur in children and adolescents. Patients with intracranial germinomas mainly manifest with hypothalamic pituitary axis dysfunction and/or compression syndromes. Visual disturbance is one of the most significant clinical presentations, which is mainly caused by tumor cell infiltration into the optic pathway. In this article, we present three cases of patient with intracranial germinoma to analyze the ocular manifestations. All the three patients presented with endocrine symptoms in the early stage and with visual disturbances (including decreased visual acuity and visual field defects) later. In general, germinoma is diagnosed by its characteristic radiological appearance, supported by tumor markers and/or stereotactic biopsy. However, decisive diagnoses were established when ocular manifestations were presented. A suspicion for germinoma should be considered, when young patients manifest visual disturbances accompanied by endocrine symptoms.
颅内生殖细胞瘤是来源于性腺的恶性肿瘤，在年龄、性别和临床表现方面具有一些特征。它们主要发生在儿童和青少年中。颅内生殖细胞瘤患者主要表现为下丘脑-垂体轴功能障碍和/或压迫综合征。视力障碍是最显著的临床表现之一，主要是由于肿瘤细胞浸润视神经通路所致。在本文中，我们介绍了 3 例颅内生殖细胞瘤患者的病例，以分析眼部表现。所有 3 例患者早期均有内分泌症状，后期均有视力障碍（包括视力下降和视野缺损）。一般来说，生殖细胞瘤的诊断依据是其特征性的影像学表现，并结合肿瘤标志物和/或立体定向活检进行支持。然而，当出现眼部表现时，诊断结果就具有决定性。当年轻患者出现伴有内分泌症状的视力障碍时，应考虑生殖细胞瘤的可能性。
