Ng H K
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Acta Cytol. 1995 Jul-Aug;39(4):693-7.
Although cytologic smear preparations have been used in the intraoperative diagnosis of central nervous system tumors for a long time, detailed descriptions of the rarer tumors, including germinomas, have not been provided in the literature. We reviewed the cytologic features of five intracranial germinomas diagnosed with the smear technique. The smears showed sheets of large tumor cells intimately mixed with mature lymphocytes. The cells had delicate, vacuolated cytoplasm with distinct borders, while the nucleoli were prominent and elongated. There often was an amorphous, eosinophilic background of extracellular matrix. The main differential diagnoses were true pineal gland tumors, pituitary adenomas, craniopharyngiomas, pilocytic astrocytomas and parasellar meningiomas.
尽管细胞学涂片制备技术长期以来一直用于中枢神经系统肿瘤的术中诊断，但包括生殖细胞瘤在内的罕见肿瘤的详细描述在文献中尚未见报道。我们回顾了采用涂片技术诊断的5例颅内生殖细胞瘤的细胞学特征。涂片显示大片大肿瘤细胞与成熟淋巴细胞紧密混合。细胞具有细腻、空泡状的细胞质，边界清晰，而核仁突出且细长。细胞外基质常有无定形的嗜酸性背景。主要鉴别诊断包括真性松果体肿瘤、垂体腺瘤、颅咽管瘤、毛细胞型星形细胞瘤和鞍旁脑膜瘤。
