Zhang Yuan, Xi Lin, Zhao Yan-ming, Zhao Li-ping, Zhang Luo
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Jun;47(6):476-80.
To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) in the interleukin-1 receptor-associated kinase 4 (IRAK-4) gene and allergic rhinitis (AR).
A population of 379 patients with the diagnosis of AR and 333 healthy controls who lived in Beijing region was recruited. A total of 8 reprehensive marker SNP which were in IRAK-4 gene region were selected according to the Beijing people database from Hapmap website. The individual genotyping was performed by MassARRAY platform. SPSS 13.0 software was used for statistic analysis.
Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262: P = 0.0034, OR = 1.7388; rs4251481: P = 0.0023, OR = 2.6593), but not in subjects who were allergic to pollens as well as mix allergens.
The potential genetic contribution of the IRAK-4 gene to AR demonstrated an allergen-dependant association pattern in Chinese population.
研究白细胞介素-1受体相关激酶4（IRAK-4）基因单核苷酸多态性（SNP）与变应性鼻炎（AR）之间的遗传关联模式。
招募了379例诊断为AR的患者和333例居住在北京地区的健康对照者。根据Hapmap网站的北京人群数据库，从IRAK-4基因区域选择了8个代表性标记SNP。通过MassARRAY平台进行个体基因分型。使用SPSS 13.0软件进行统计分析。
对不同过敏原敏感性存在情况的亚组分析显示，仅在屋尘螨过敏队列中有关联（rs3794262：P = 0.0034，OR = 1.7388；rs4251481：P = 0.0023，OR = 2.6593），而在对花粉以及混合过敏原过敏的受试者中未发现关联。
在中国人群中，IRAK-4基因对AR的潜在遗传贡献表现出过敏原依赖性关联模式。
