Penn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia,
Circulation. 2012 Oct 2;126(14):1681-8. doi: 10.1161/CIRCULATIONAHA.112.095216. Epub 2012 Aug 29.
Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline.
The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P<0.001) and a doubling (or more) of risk with left ventricular mass at the mean value or lower (P for interaction=0.05).
RV hypertrophy was associated with the risk of heart failure or death in a multiethnic population free of clinical cardiovascular disease at baseline.
右心室 (RV) 形态的变化与心脏和肺部疾病的发病率和死亡率有关。我们在一个无临床心血管疾病的多民族基础人群中，研究了 RV 结构和功能异常与心力衰竭或心血管死亡风险之间的关系。
动脉粥样硬化多民族研究 (MESA) 在 2000 年至 2002 年间对 5098 名参与者进行了心脏磁共振成像检查，并对无临床心血管疾病的基线参与者进行了心力衰竭和心血管死亡 ("死亡") 的随访。RV 容积和质量可用于 4204 名参与者。研究样本（n=4144）年龄为 61.4±10.1 岁，47.6%为男性。RV 肥厚（RV 质量增加）的存在与心力衰竭或死亡的风险增加两倍以上，调整了人口统计学、体重指数、教育、C-反应蛋白水平、高血压和吸烟状况后（风险比，2.52；95%置信区间，1.55-4.10；P<0.001），且在平均或更低的左心室质量时风险增加一倍或更多（P 交互=0.05）。
在无临床心血管疾病的多民族人群中，RV 肥厚与心力衰竭或死亡的风险相关。
