证据表明，CD3+ T 淋巴细胞对马动脉炎病毒感染的体外敏感性反映了自然感染的种马成为病毒携带者的遗传易感性。
Evidence that in vitro susceptibility of CD3+ T lymphocytes to equine arteritis virus infection reflects genetic predisposition of naturally infected stallions to become carriers of the virus.
机构信息
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA.
出版信息
J Virol. 2012 Nov;86(22):12407-10. doi: 10.1128/JVI.01698-12. Epub 2012 Aug 29.
Abstract
We investigated the correlation between in vitro susceptibility of CD3(+) T lymphocytes to equine arteritis virus (EAV) infection and establishment of persistent infection among 14 stallions following natural infections. The data showed that carrier stallions with a CD3(+) T lymphocyte susceptibility phenotype to in vitro EAV infection may be at higher risk of becoming carriers than those that lack this phenotype (P = 0.0002).
摘要
我们研究了 14 匹种马自然感染后，CD3(+) T 淋巴细胞对马动脉炎病毒（EAV）感染的体外易感性与持续性感染建立之间的相关性。数据显示，与缺乏这种表型的种马相比，具有体外 EAV 感染 CD3(+) T 淋巴细胞易感性表型的携带种马可能更有成为携带病毒者的风险（P = 0.0002）。
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