碘海醇的血浆清除率和肾脏清除率——肾小球滤过率测定方法的可重复性研究

Plasma and renal clearance of iohexol--a study on the reproducibility of a method for the glomerular filtration rate.

作者信息

Arvidsson A, Hedman A

机构信息

Department of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden.

出版信息

Scand J Clin Lab Invest. 1990 Nov;50(7):757-61. doi: 10.3109/00365519009091069.

DOI:10.3109/00365519009091069

PMID:2293336

Abstract

The reproducibility of iohexol clearance as a determination of the glomerular filtration rate was assessed in 12 healthy subjects during triplicate constant-rate infusions. Renal and plasma clearance of iohexol demonstrated a total within-subject variation (CV) ranging between 0% and 16%. The inter-individual variation in renal clearance was about 10%, the clearance values being (mean +/- SD) 116 +/- 10, 117 +/- 9 and 110 +/- 12 ml/min 1.73 m2 in the three experiments and corresponding figures for the plasma clearance were 120 +/- 17, 118 +/- 12 and 112 +/- 14 ml/min 1.73 m2. The renal clearance (CLR) and the plasma clearance (CL) showed good correlation (regression equation CL = 11.80 + 0.93 CLR, rs = 0.67). The method is simple and reproducible; thus, it is suitable for both clinical examinations and research.

摘要

在12名健康受试者进行三次恒速输注期间，评估了碘海醇清除率作为肾小球滤过率测定方法的可重复性。碘海醇的肾清除率和血浆清除率显示受试者内总变异（CV）在0%至16%之间。肾清除率的个体间变异约为10%，三次实验中的清除率值（均值±标准差）分别为116±10、117±9和110±12 ml/min/1.73 m²，血浆清除率的相应数值分别为120±17、118±12和112±14 ml/min/1.73 m²。肾清除率（CLR）和血浆清除率（CL）显示出良好的相关性（回归方程CL = 11.80 + 0.93 CLR，rs = 0.67）。该方法简单且可重复，因此适用于临床检查和研究。