Chandler Angela L, Hobbs Charlotte A, Mosley Bridget S, Berry Robert J, Canfield Mark A, Qi Yan Ping, Siega-Riz Anna Maria, Shaw Gary M
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 72202, USA.
Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):864-74. doi: 10.1002/bdra.23068. Epub 2012 Aug 29.
Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.
Using data from the National Birth Defects Prevention Study, 1997-2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.
Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B(6) , vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.
In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B(6) , vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
已对孕妇营养状况进行评估，以阐明其在神经管缺陷（NTDs）发生发展中的作用。孕期孕妇叶酸摄入量与NTDs的关联已得到密切评估。本研究的目的是探讨NTDs与其他孕前膳食微量营养素摄入量之间的关联，特别是参与一碳代谢或抗氧化活性的营养素。
利用1997 - 2005年国家出生缺陷预防研究的数据，采用逻辑回归模型根据孕妇微量营养素摄入量估计NTDs的相对风险。
根据叶酸补充剂使用情况、种族/民族和孕妇体重指数对结果进行分层。分析纳入了954例病例（300例无脑儿，654例脊柱裂）和6268例对照。在一些种族和临床组中，较高的叶酸、硫胺素、甜菜碱、铁和维生素A摄入量与无脑儿风险降低相关。在一些组中，较高的硫胺素、核黄素、维生素B6、维生素C、维生素E、烟酸和视黄醇摄入量与脊柱裂风险降低相关。
除叶酸外，其他微量营养素，包括硫胺素、甜菜碱、核黄素、维生素B6、维生素C、维生素E、烟酸、铁、视黄醇和维生素A，可能会降低NTDs的发生风险。《出生缺陷研究（A部分）》2012年。©2012威利期刊公司。
