马来西亚散发型伤寒病例相关的伤寒沙门氏菌血清型 Typhi 株基因组序列的研究结果。
Insights from the genome sequence of a Salmonella enterica serovar Typhi strain associated with a sporadic case of typhoid fever in Malaysia.
机构信息
Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
J Bacteriol. 2012 Sep;194(18):5124-5. doi: 10.1128/JB.01062-12.
Abstract
Salmonella enterica serovar Typhi is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths globally. Herein, we describe the whole-genome sequence of the Salmonella Typhi strain ST0208, isolated from a sporadic case of typhoid fever in Kuala Lumpur, Malaysia. The whole-genome sequence and comparative genomics allow an in-depth understanding of the genetic diversity, and its link to pathogenicity and evolutionary dynamics, of this highly clonal pathogen that is endemic to Malaysia.
摘要
伤寒沙门氏菌血清型 Typhi 是伤寒的病原体，在全球范围内导致近 2170 万例疾病和 21.7 万人死亡。在此，我们描述了从马来西亚吉隆坡的一起散发性伤寒病例中分离到的伤寒沙门氏菌 ST0208 菌株的全基因组序列。全基因组序列和比较基因组学使我们能够深入了解这种高度克隆的病原体的遗传多样性，以及它与马来西亚地方性病原体的致病性和进化动态的关系。
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