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对源自菲律宾的与旅行相关的产超广谱β-内酰胺酶伤寒沙门氏菌血清型伤寒杆菌分离株进行基因组剖析：是一次性事件还是对伤寒热有效治疗的威胁？

Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?

作者信息

Hendriksen Rene S, Leekitcharoenphon Pimlapas, Mikoleit Matthew, Jensen Jacob Dyring, Kaas Rolf Sommer, Roer Louise, Joshi Heena B, Pornruangmong Srirat, Pulsrikarn Chaiwat, Gonzalez-Aviles Gladys D, Reuland E Ascelijn, Al Naiemi Nashwan, Wester Astrid Louise, Aarestrup Frank M, Hasman Henrik

机构信息

Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark

Technical University of Denmark, National Food Institute, WHO Collaborating Centre for Antimicrobial Resistance in Foodborne Pathogens and European Union Reference Laboratory for Antimicrobial Resistance, Kongens Lyngby, Denmark.

出版信息

J Clin Microbiol. 2015 Feb;53(2):677-80. doi: 10.1128/JCM.03104-14. Epub 2014 Nov 26.

DOI:10.1128/JCM.03104-14
PMID:25428145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4298498/
Abstract

One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi.

摘要

鉴定出1例产超广谱β-内酰胺酶（ESBL）的伤寒沙门氏菌肠炎血清型菌株，除其他分析外，还进行了全基因组序列分型，并与其他可用的伤寒沙门氏菌基因组进行了比较。报告的菌株与先前发表的来自菲律宾的携带blaSHV-12的菌株相似，可能是未被发现的疫情的一部分，这是首例产ESBL的伤寒沙门氏菌。

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