少突胶质细胞瘤的遗传标志物。
Genetic markers in oligodendroglial tumours.
机构信息
Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia.
出版信息
Radiol Oncol. 2010 Mar;44(1):13-8. doi: 10.2478/v10019-010-0007-y. Epub 2010 Mar 18.
Abstract
BACKGROUND
Oliogodendrogliomas are brain tumours composed of the cells resembling oligodendrocytes. They represent the third most common glial tumour, comprising 2.5% of all primary brain tumours and 5-20% of all gliomas.
CONCLUSIONS
Oligodendroglial tumours with 1p and 19q loss demonstrate a better overall prognosis due to more indolent clinical behaviour and higher sensitivity to treatment. Additionally, 1p and 19q loss is a marker of clinical utility, helping to assess tumour sensitivity to chemotherapy and harbouring the potential for improving the diagnosis and survival of oligodendroglioma patients as well as future clinical practice.
摘要
背景
少突胶质细胞瘤是由类似于少突胶质细胞的细胞组成的脑肿瘤。它们是第三常见的神经胶质瘤，占所有原发性脑肿瘤的 2.5%，占所有神经胶质瘤的 5-20%。
结论
由于具有更惰性的临床行为和对治疗更高的敏感性，1p 和 19q 缺失的少突胶质细胞瘤具有更好的总体预后。此外，1p 和 19q 缺失是临床实用性的标志物，有助于评估肿瘤对化疗的敏感性，并有可能改善少突胶质细胞瘤患者的诊断和生存以及未来的临床实践。
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