Cancer and Inflammation Program; National Cancer Institute; Frederick, MD USA ; Basic Science Program; SAIC-Frederick, Inc.; Frederick, MD USA.
Oncoimmunology. 2012 Aug 1;1(5):780-782. doi: 10.4161/onci.19731.
CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8(+) T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
CpG 寡核苷酸通过 TLR9 刺激并增强抗肿瘤免疫，这种作用归因于 NK 和 CD8(+) T 细胞的激活。我们最近的工作表明，CpG ODN 还诱导单核细胞来源的髓系抑制细胞成熟为 M1 巨噬细胞，进一步有助于肿瘤消除。这为 CpG 促进肿瘤消退的机制提供了深入了解。
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