Plant Virology Research Center, Shiraz University, Shiraz 71441-65186, Iran.
Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland.
Int J Mol Sci. 2021 Jul 5;22(13):7239. doi: 10.3390/ijms22137239.
Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.
巨噬细胞是先天免疫系统中最重要的细胞之一，以吞噬和消化异物（包括细胞碎片和肿瘤细胞）的能力而闻名。当成熟的巨噬细胞被招募到肿瘤微环境中时，它们可以转化为肿瘤相关巨噬细胞（TAMs）。它们在癌症进展、转移和治疗失败中的作用特别值得注意。本综述的目的是了解 TAMs 的存在在免疫系统中是如何既有优势又有劣势的。
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