无催化剂的 N-烯丙基苯甲酰胺分子内氧化环化反应：合成 2,5-取代恶唑的新途径。

Catalyst-free intramolecular oxidative cyclization of N-allylbenzamides: a new route to 2,5-substituted oxazoles.

机构信息

School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.

出版信息

Org Lett. 2012 Sep 21;14(18):4766-9. doi: 10.1021/ol302031z. Epub 2012 Aug 30.

DOI:10.1021/ol302031z

PMID:22934604

Abstract

A catalyst-free intramolecular oxidative cyclization reaction of N-allylbenzamides has been developed to prepare 2,5-disubstituted oxazoles with good yields. This reaction gives an efficient synthetic strategy to form an oxazole nucleus directly from easily accessible substrates under temperate conditions.

摘要

发展了一种 N-烯丙基苯甲酰胺的无催化剂分子内氧化环化反应，以高产率制备 2,5-二取代恶唑。该反应提供了一种在温和条件下直接从易得的底物形成恶唑核的有效合成策略。