北美杯蕈属真菌 U. craterium 中的抗菌螺二萘并呋喃。

Antibacterial spirobisnaphthalenes from the North American cup fungus Urnula craterium.

机构信息

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.

出版信息

J Nat Prod. 2012 Sep 28;75(9):1534-8. doi: 10.1021/np300221a. Epub 2012 Aug 30.

DOI:10.1021/np300221a

PMID:22934636

Abstract

Urnucratins A-C (1-3), which possess an unusual bisnaphthospiroether skeleton with one oxygen bridge and one C-C bridge and represent a new subclass of bisnaphthalenes, were isolated from the North American cup fungus Urnula craterium. Their structures, including absolute configurations, were determined by means of HRMS, NMR, and quantum chemical CD calculations. Urnucratin A (1) was found to be active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and Streptococcus pyogenes with MIC values of 2, 1, and 0.5 μg/mL, respectively.

摘要

Urnucratins A-C（1-3），它们具有不寻常的双萘并螺环醚骨架，其中包含一个氧桥和一个 C-C 桥，代表了双萘并类的一个新亚类，从北美的杯状真菌 Urnula craterium 中分离得到。它们的结构，包括绝对构型，是通过高分辨质谱、NMR 和量子化学 CD 计算来确定的。Urnucratin A（1）被发现对耐甲氧西林金黄色葡萄球菌、万古霉素耐药粪肠球菌和化脓性链球菌具有活性，其 MIC 值分别为 2、1 和 0.5 μg/mL。