内生真菌 Berklesasmium sp. Dzf12 液体培养中添加 1-十六烯对 palmarumycin C2 和 C3 产量的影响及其抗菌和抗氧化活性。

MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

Molecules. 2013 Dec 13;18(12):15587-99. doi: 10.3390/molecules181215587.

Two spirobisnaphthalenes, namely palmarumycins C2 and C3, were isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. After addition of 1-hexadecene at 10% to the medium on day 6 of culture, the maximal yields of palmarumycins C2 and C3 were obtained as 0.40 g/L and 1.19 g/L, which were 40.00 fold and 59.50 fold higher, respectively, in comparison with those of the control (0.01 g/L and 0.02 g/L). The results indicated that addition of 1-hexadecene can be an effective strategy for enhancing the production of palmarumycins C2 and C3 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Palmarumycin C3 exhibited stronger antimicrobial and antioxidant activities than palmarumycin C2.

两种螺环二萘并呋喃类化合物，即 palmarmycins C2 和 C3，从内生真菌 Berklesa sp. Dzf12 的培养物中分离出来，经过 1-十六烯处理后。在培养第 6 天向培养基中添加 10%的 1-十六烯后，palmarmycins C2 和 C3 的最大产量分别为 0.40 g/L 和 1.19 g/L，分别比对照（0.01 g/L 和 0.02 g/L）高 40.00 倍和 59.50 倍。结果表明，在 Berklesa sp. Dzf12 的内生真菌液体培养中添加 1-十六烯可以作为一种有效提高 palmarmycins C2 和 C3 产量的策略。与 palmarmycin C2 相比，palmarmycin C3 具有更强的抗菌和抗氧化活性。