Finch Amy, Evans Gareth, Narod Steven A
Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Womens Health (Lond). 2012 Sep;8(5):543-55. doi: 10.2217/whe.12.41.
Women who inherit a mutation in either the BRCA1 or BRCA2 gene have greatly elevated lifetime risks of ovarian cancer, fallopian tube cancer and breast cancer. Preventive surgical removal of the ovaries and fallopian tubes (salpingo-oophorectomy) is recommended to these women, often prior to natural menopause, to prevent cancer. The ensuing hormone deprivation may impact on health and quality of life. Most of these women experience menopausal symptoms shortly after surgery; however, there may also be longer term consequences that are less well understood. In this review, we highlight recent studies that examine the implications of salpingo-oophorectomy on health and quality of life in BRCA-positive women and we discuss the care of women following prophylactic surgery.
携带BRCA1或BRCA2基因突变的女性一生中患卵巢癌、输卵管癌和乳腺癌的风险会大幅升高。建议这些女性在自然绝经前预防性切除卵巢和输卵管（输卵管卵巢切除术）以预防癌症。随之而来的激素缺乏可能会影响健康和生活质量。这些女性中的大多数在手术后不久就会出现更年期症状；然而，可能还存在一些尚不为人所熟知的长期后果。在本综述中，我们重点介绍了近期研究，这些研究探讨了输卵管卵巢切除术对BRCA基因阳性女性健康和生活质量的影响，并讨论了预防性手术后女性的护理问题。
