Faculty of Health, Medicine and Life Science, University Maastricht, Faculty of Health, Medicine and Life Science, UNS 40 room 4.550, PO Box 3100 6202 NC Maastricht, The Netherlands.
Curr Med Chem. 2012;19(33):5607-11. doi: 10.2174/092986712803988901.
Medicinal agents, beside occupational and environmental agents, remain one of the most common causes for interstitial lung diseases (ILD). A major problem with ILD is the recognition of the causative agent. In some cases more or less characteristic features of presentation are described. Often, the connection between drug-use and the development of related inflammatory damage or idiosyncratic toxicities is hard to recognize and objectify. Cocaine, a xenobiotic and the most commonly used illicit drug, causes serious medical and social problems. An increasing incidence of lung toxicity related to cocaine or crack-use is being reported worldwide. However, the mechanism of the resulting lung injury is not fully understood. This review summarizes possible molecular mechanisms explaining intraindividual variability in cocaine response and lung toxicity. The importance of including pharmacogenomics in the work-up of patients with suspected drug-induced lung toxicity is highlighted.
药物，除了职业和环境因素外，仍然是间质性肺疾病（ILD）的最常见原因之一。ILD 的一个主要问题是识别致病因素。在某些情况下，描述了或多或少具有特征性表现的特征。通常，药物使用与相关炎症损伤或特发性毒性之间的联系很难识别和客观化。可卡因是一种异生物和最常用的非法药物，它会导致严重的医疗和社会问题。全世界都在报告与可卡因或快克使用相关的肺毒性发生率不断增加。然而，导致肺损伤的机制尚未完全阐明。这篇综述总结了可能的分子机制，解释了个体对可卡因反应和肺毒性的个体差异。强调了在疑似药物引起的肺毒性患者的检查中纳入药物基因组学的重要性。
