Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, U.S.A.
Curr Med Chem. 2012;19(33):5726-34. doi: 10.2174/092986712803988866.
Plague is an infectious disease with a high mortality rate that has repeatedly impacted human society. It remains a threat in many parts of the world today. Plague is caused by the bacterium, Yersinia pestis (Y. pestis), which has as one of its required virulence factors, the protein-tyrosine phosphatase, YopH. Therefore, YopH represents a potential target for the treatment of Y. pestis infection. Recent recognition of Y. pestis as a possible bioterrorism agent and the fact that it is still the cause of endemic disease around the world make it an important object of study and heighten the need for new anti-plague agents. The current review covers aspects of plague and its historical occurrence and summarizes approaches to developing YopH inhibitors.
鼠疫是一种死亡率很高的传染病，曾多次对人类社会造成影响。时至今日，它在世界上的许多地方仍然构成威胁。鼠疫是由细菌鼠疫耶尔森菌（Yersinia pestis，Y. pestis）引起的，该细菌的一种必需毒力因子是蛋白酪氨酸磷酸酶 YopH。因此，YopH 代表了治疗鼠疫耶尔森菌感染的潜在靶点。最近，人们认识到鼠疫耶尔森菌可能是一种生物恐怖主义制剂，而且它仍然是世界各地地方性疾病的病因，这使得它成为一个重要的研究对象，并增加了对新型抗鼠疫制剂的需求。本综述涵盖了鼠疫及其历史发生的各个方面，并总结了开发 YopH 抑制剂的方法。
