Horváth Gábor, Farkas Klaudia, Hollósi Renáta, Nagy Ferenc, Szepes Zoltán, Papp Mária, Palatka Károly, Miheller Pál, Lakatos László, Szamosi Tamás, Nyári Tibor, Wittmann Tibor, Molnár Tamás
Department of Gastroenterology, Semmelweis Health Centre of Miskolc, Miskolc, Hungary.
Scand J Gastroenterol. 2012 Nov;47(11):1298-303. doi: 10.3109/00365521.2012.703233. Epub 2012 Aug 31.
Inflammatory bowel diseases (IBD) have a huge impact on the patients' lives and require continuous medication and long-term medical follow-up. The Short Form Health Survey (SF-36) is a commonly used questionnaire measuring health-related quality of life (HRQOL). Our aim was to evaluate whether HRQOL influences medication adherence and vice versa in IBD patients, and to find relationships between demographic parameters, therapeutic modalities and non-adherence or HRQOL.
Five hundred ninety-two IBD patients treated at six Hungarian tertiary centers were enrolled. Patients completed the SF-36 questionnaire and a medication adherence report scale during their visits. The associations between demographic parameters, HRQOL, different kinds of therapies and non-adherence were analyzed.
The most affected dimension was physical functioning and least affected were the social functions. About 42.7% of the patients revealed their HRQOL to be acceptable. About 74.6% of the patients believed that the prescribed medications actually improved their HRQOL. Diarrhea was the most common and most severe symptom during the course of the disease. Non-adherence was reported in 13.4% of the patients. 'Forgetting to take the medication' was the main reason for non-adherence in 67.6% of the cases. Medication adherence was significantly higher among nonsmoker patients, and also in the case of immunomodulator therapy. There was no association between the sum of HRQOL and different subscores and non-adherence.
Inflammatory bowel disease is associated with low HRQOL, which is not affected by drug therapy. The impaired quality of life in IBD is mainly influenced by the disease itself.
炎症性肠病（IBD）对患者生活有巨大影响，需要持续用药及长期医学随访。简明健康调查量表（SF - 36）是一种常用的用于测量健康相关生活质量（HRQOL）的问卷。我们的目的是评估HRQOL是否影响IBD患者的用药依从性，反之亦然，并找出人口统计学参数、治疗方式与不依从或HRQOL之间的关系。
纳入在匈牙利六个三级中心接受治疗的592例IBD患者。患者在就诊期间完成SF - 36问卷和用药依从性报告量表。分析人口统计学参数、HRQOL、不同治疗方法与不依从之间的关联。
受影响最大的维度是身体功能，受影响最小的是社会功能。约42.7%的患者表示其HRQOL可接受。约74.6%的患者认为所开药物确实改善了他们的HRQOL。腹泻是疾病过程中最常见和最严重的症状。13.4%的患者报告有不依从情况。67.6%的病例中，“忘记服药”是不依从的主要原因。不吸烟患者的用药依从性显著更高，免疫调节剂治疗的情况也是如此。HRQOL总和及不同子分数与不依从之间无关联。
炎症性肠病与低HRQOL相关，且不受药物治疗影响。IBD患者生活质量受损主要受疾病本身影响。
