Farcas N, Arzi B, Verstraete F J M
William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
Vet Comp Oncol. 2014 Sep;12(3):169-80. doi: 10.1111/j.1476-5829.2012.00352.x. Epub 2012 Aug 31.
Osteosarcoma in dogs is a heterogeneous disease entity with regard to its histologic, clinical and biologic behaviour. Differences in behaviour are associated with tumour location. Oral and maxillofacial osteosarcomas are typically reported as a component of the broader classifications of axial osteosarcoma or osteosarcoma of flat bones to differentiate them from appendicular osteosarcoma. Similar to human oral and maxillofacial osteosarcoma, in dogs, these also appear to have less aggressive behaviour than appendicular osteosarcoma. Ideally, local control is achieved with wide surgical resection that results in tumour-free margins. Failure of local control is the most common contributor to poor prognosis. Chemotherapy and radiation treatment are reported to have variable outcomes. The aim of this article is to review the literature on oral and maxillofacial osteosarcoma in dogs in comparison to appendicular and axial osteosarcoma. Similarities and differences between oral and maxillofacial osteosarcoma in humans are addressed.
犬骨肉瘤在组织学、临床和生物学行为方面是一种异质性疾病实体。行为差异与肿瘤位置有关。口腔颌面部骨肉瘤通常被报道为轴向骨肉瘤或扁骨骨肉瘤更广泛分类的一个组成部分，以便将它们与四肢骨肉瘤区分开来。与人类口腔颌面部骨肉瘤相似，在犬类中，这些肿瘤的行为似乎也比四肢骨肉瘤的侵袭性小。理想情况下，通过广泛的手术切除实现局部控制，从而获得无肿瘤切缘。局部控制失败是预后不良的最常见原因。据报道，化疗和放疗的效果各不相同。本文的目的是回顾犬口腔颌面部骨肉瘤与四肢和轴向骨肉瘤相比的相关文献。文中还讨论了人类口腔颌面部骨肉瘤之间的异同。
