Poliquin C M
Jean Marie Colbert Bone Marrow Transplant Center, University of Connecticut Health Center, Farmington.
Yale J Biol Med. 1990 Sep-Oct;63(5):495-502.
Increasingly, bone marrow transplant (BMT) is the treatment of choice for certain hematologic diseases. BMT is, however, a risky procedure with many potentially serious complications. Some complications are the result of the conditioning regimen, a stage of transplantation that includes large doses of chemotherapy and/or radiation therapy. Conditioning-induced neutropenia and thrombocytopenia often result in infection, bleeding, and mucositis. Veno-occlusive disease (VOD), a chemotherapy-induced hepatotoxicity, can cause a mild to severe form of liver disease. Other complications are directly attributable to the engrafted new marrow. Graft-versus-host disease, a rejection process initiated by immunocompetent donor T lymphocytes, is a complication frequently observed in allogeneic BMT. Approximately 14-28 days after the day of transplant, signs of engraftment begin to appear. When specific discharge criteria are met, the BMT patient is discharged from the hospital. Specific follow-up medical care is ongoing for about one year after BMT.
骨髓移植（BMT）越来越成为某些血液系统疾病的首选治疗方法。然而，BMT是一种有风险的手术，存在许多潜在的严重并发症。一些并发症是预处理方案的结果，预处理是移植的一个阶段，包括大剂量化疗和/或放疗。预处理引起的中性粒细胞减少和血小板减少常导致感染、出血和粘膜炎。静脉闭塞性疾病（VOD）是一种化疗引起的肝毒性，可导致轻度至重度肝病。其他并发症直接归因于植入的新骨髓。移植物抗宿主病是由具有免疫活性的供体T淋巴细胞引发的排斥反应过程，是异基因BMT中经常观察到的并发症。移植后约14 - 28天，开始出现植入迹象。当满足特定出院标准时，BMT患者即可出院。BMT后约一年需持续进行特定的后续医疗护理。
