Chaves Roberta Nogueira, de Matos Maria Helena Tavares, Buratini José, de Figueiredo José Ricardo
Laboratory of Manipulation of Oocytes and Preantral Follicles, State University of Ceará, Fortaleza, 60740-903, CE, Brazil.
Reprod Fertil Dev. 2012;24(7):905-15. doi: 10.1071/RD11318.
Several growth factors have been identified as local regulators of follicle development and ovulation. Fibroblast growth factor (FGF) family members are potent mitogens and are involved in cell differentiation, cell migration and angiogenesis in many tissues and organs. In addition to FGF-2, which is the most-studied FGF, other important members are FGF-1, -5, -7, -8, -9 and -10. A number of studies have indicated that FGFs play important roles in regulating the initiation of primordial follicle growth, oocyte and follicle survival, granulosa and theca cell proliferation and differentiation, corpus luteum formation, steroidogenesis and angiogenesis. The purpose of this review is to highlight the importance of the FGFs on mammalian female reproduction, providing a better understanding of the roles of this family in ovarian physiology and female fertility.
几种生长因子已被确定为卵泡发育和排卵的局部调节因子。成纤维细胞生长因子（FGF）家族成员是强效的促有丝分裂原，参与许多组织和器官中的细胞分化、细胞迁移和血管生成。除了研究最多的FGF-2外，其他重要成员还有FGF-1、-5、-7、-8、-9和-10。多项研究表明，FGF在调节原始卵泡生长的启动、卵母细胞和卵泡存活、颗粒细胞和卵泡膜细胞增殖与分化、黄体形成、类固醇生成和血管生成中发挥重要作用。本综述的目的是强调FGF对哺乳动物雌性生殖的重要性，以便更好地理解该家族在卵巢生理学和雌性生育能力中的作用。
