Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Circ Res. 2012 Aug 31;111(6):800-14. doi: 10.1161/CIRCRESAHA.111.255505.
AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.
腺苷酸活化蛋白激酶 (AMPK) 是一种应激激活的激酶，作为细胞燃料表和主要代谢调节剂发挥作用。最近的研究阐明了 AMPK 调节的新分子机制和 AMPK 途径的重要生物学作用，这些作用与心血管疾病高度相关。内在 AMPK 途径的激活在心肌对缺血、压力超负荷和心力衰竭的反应中起着重要作用。AMPK 的药理学激活有望成为心脏病治疗的一种治疗策略。本综述的目的是评估最近的发现如何扩展和在某些情况下挑战现有的范例，为 AMPK 的调节、其多样化的生物学作用以及心脏中的治疗潜力提供新的见解。
