AMP 激活的蛋白激酶在心脏中的调节和生物学作用。
AMP-activated protein kinase regulation and biological actions in the heart.
机构信息
Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
出版信息
Circ Res. 2012 Aug 31;111(6):800-14. doi: 10.1161/CIRCRESAHA.111.255505.
Abstract
AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart.
摘要
腺苷酸活化蛋白激酶 (AMPK) 是一种应激激活的激酶，作为细胞燃料表和主要代谢调节剂发挥作用。最近的研究阐明了 AMPK 调节的新分子机制和 AMPK 途径的重要生物学作用，这些作用与心血管疾病高度相关。内在 AMPK 途径的激活在心肌对缺血、压力超负荷和心力衰竭的反应中起着重要作用。AMPK 的药理学激活有望成为心脏病治疗的一种治疗策略。本综述的目的是评估最近的发现如何扩展和在某些情况下挑战现有的范例，为 AMPK 的调节、其多样化的生物学作用以及心脏中的治疗潜力提供新的见解。
相似文献
1
AMP-activated protein kinase regulation and biological actions in the heart.AMP 激活的蛋白激酶在心脏中的调节和生物学作用。
Circ Res. 2012 Aug 31;111(6):800-14. doi: 10.1161/CIRCRESAHA.111.255505.
2
AMP-activated protein kinase in the heart: role during health and disease.心脏中的AMP激活蛋白激酶：健康与疾病状态下的作用
Circ Res. 2007 Mar 2;100(4):474-88. doi: 10.1161/01.RES.0000258446.23525.37.
3
AMP-activated protein kinase: a core signalling pathway in the heart.AMP 激活的蛋白激酶：心脏中的核心信号通路。
Acta Physiol (Oxf). 2009 May;196(1):37-53. doi: 10.1111/j.1748-1716.2009.01978.x. Epub 2009 Feb 23.
4
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response.脂联素缺乏通过破坏 AMPK 依赖性血管生成反应加重压力超负荷后的心脏功能障碍。
J Mol Cell Cardiol. 2010 Aug;49(2):210-20. doi: 10.1016/j.yjmcc.2010.02.021. Epub 2010 Mar 4.
5
[Effect of AMP-activated protein kinase on cardiovascular protection of adiponectin].[AMP激活蛋白激酶对脂联素心血管保护作用的影响]
Sheng Li Xue Bao. 2007 Oct 25;59(5):614-8.
6
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.AMP激活的蛋白激酶通路：心脏代谢疾病的一个潜在治疗靶点。
Clin Sci (Lond). 2009 Apr;116(8):607-20. doi: 10.1042/CS20080066.
7
Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway.Notch1通过依赖LKB1的AMPK信号通路对心肌梗死的心脏保护作用。
Biochem Pharmacol. 2016 May 15;108:47-57. doi: 10.1016/j.bcp.2016.03.019. Epub 2016 Mar 22.
8
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.AMP激活的蛋白激酶：一种在心血管系统中具有关键作用的普遍存在的信号通路。
Circ Res. 2017 May 26;120(11):1825-1841. doi: 10.1161/CIRCRESAHA.117.309633.
9
AMPK in cardiovascular health and disease.AMPK 在心血管健康和疾病中的作用。
Acta Pharmacol Sin. 2010 Sep;31(9):1075-84. doi: 10.1038/aps.2010.139. Epub 2010 Aug 16.
10
The role of phospho-adenosine monophosphate-activated protein kinase and vascular endothelial growth factor in a model of chronic heart failure.磷酸腺苷激活的蛋白激酶和血管内皮生长因子在慢性心力衰竭模型中的作用。
Artif Organs. 2010 Nov;34(11):969-79. doi: 10.1111/j.1525-1594.2010.01121.x.
引用本文的文献
1
Biological Actions of Alamandine: A Scoping Review.阿兰曼丁的生物学作用：一项范围综述
Biomedicines. 2025 Aug 11;13(8):1957. doi: 10.3390/biomedicines13081957.
2
Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology.AMP激活的蛋白激酶在心脏生理和病理生理中的亚型特异性作用。
Front Cardiovasc Med. 2025 Aug 8;12:1638515. doi: 10.3389/fcvm.2025.1638515. eCollection 2025.
3
Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry.通过整合自上而下质谱法揭示的单磷酸腺苷激活蛋白激酶中蛋白变体-配体复合物的结构异质性
J Am Chem Soc. 2025 Aug 14. doi: 10.1021/jacs.5c06950.
4
FSTL-1 as a Novel Cardiokine of Cardiac Angiogenesis: A Systematic Review.FSTL-1作为心脏血管生成的一种新型心脏因子：一项系统综述。
Vasc Health Risk Manag. 2025 May 27;21:437-449. doi: 10.2147/VHRM.S509482. eCollection 2025.
5
The multifaceted nature of SUMOylation in heart disease and its therapeutic potential.SUMO化修饰在心脏病中的多面性及其治疗潜力。
Mol Cell Biochem. 2025 Apr 27. doi: 10.1007/s11010-025-05286-z.
6
Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses.涉及AMPK和CLYBL乙酰化的正反馈回路将代谢重塑与炎症反应联系起来。
Cell Death Dis. 2025 Jan 25;16(1):41. doi: 10.1038/s41419-025-07362-0.
7
Syringaldehyde Alleviates Cardiac Hypertrophy Induced by Hyperglycemia in H9c2 Cells Through GLP-1 Receptor Signals.丁香醛通过GLP-1受体信号减轻高糖诱导的H9c2细胞心肌肥大
Pharmaceuticals (Basel). 2025 Jan 16;18(1):110. doi: 10.3390/ph18010110.
8
α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress-Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats.α-红没药醇：一种膳食倍半萜烯，通过调节线粒体生物发生和内质网应激-河马信号轴，减轻阿霉素诱导的大鼠急性心脏毒性中的凋亡和非凋亡细胞死亡途径。
ACS Pharmacol Transl Sci. 2024 Aug 6;7(9):2694-2705. doi: 10.1021/acsptsci.4c00108. eCollection 2024 Sep 13.
9
Comparative effects of canagliflozin and sitagliptin in chronically ischemic myocardium.卡格列净与西格列汀对慢性缺血心肌的比较作用
Vessel Plus. 2024;8. doi: 10.20517/2574-1209.2023.95. Epub 2024 Jan 11.
10
The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects.AMPKα亚基在阿尔茨海默病中的作用：深入分析与未来展望。
Heliyon. 2024 Jul 6;10(13):e34254. doi: 10.1016/j.heliyon.2024.e34254. eCollection 2024 Jul 15.
本文引用的文献
1
Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart.AMPK γ 亚基在胚胎期的表达及成年心脏中一种新型 γ2 转录本变体的鉴定。
J Mol Cell Cardiol. 2012 Sep;53(3):342-9. doi: 10.1016/j.yjmcc.2012.05.017. Epub 2012 Jun 6.
2
The ancient drug salicylate directly activates AMP-activated protein kinase.古老的药物水杨酸酯直接激活 AMP 激活的蛋白激酶。
Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.
3
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK.赖氨酸去乙酰化酶的功能解析揭示了 HDAC1 和 p300 对 AMPK 的调节作用。
Nature. 2012 Feb 8;482(7384):251-5. doi: 10.1038/nature10804.
4
AMPK isoform expression in the normal and failing hearts.AMPK 同工型在正常和衰竭心脏中的表达。
J Mol Cell Cardiol. 2012 May;52(5):1066-73. doi: 10.1016/j.yjmcc.2012.01.016. Epub 2012 Jan 31.
5
AMP-activated protein kinase regulates E3 ligases in rodent heart.AMP 激活的蛋白激酶调节啮齿动物心脏中的 E3 连接酶。
Circ Res. 2011 Oct 28;109(10):1153-61. doi: 10.1161/CIRCRESAHA.111.252742. Epub 2011 Sep 15.
6
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis.过氧化氢差异调节心肌细胞一氧化氮合成。
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15792-7. doi: 10.1073/pnas.1111331108. Epub 2011 Sep 6.
7
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.抑制 5'-核苷酸酶可促进人和鼠骨骼肌中 AMP 激活的蛋白激酶（AMPK）的磷酸化和代谢。
J Biol Chem. 2011 Oct 7;286(40):34567-74. doi: 10.1074/jbc.M111.268292. Epub 2011 Aug 26.
8
AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.AMP 激活的蛋白激酶-α2 调节代谢转录因子雌激素相关受体-α的表达，该因子与心力衰竭的发展有关。
Hypertension. 2011 Oct;58(4):696-703. doi: 10.1161/HYPERTENSIONAHA.111.174128. Epub 2011 Aug 8.
9
AMP-activated protein kinase: also regulated by ADP?腺苷酸活化蛋白激酶：也受 ADP 调节？
Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
10
AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy.AMP 激活的蛋白激酶调节糖尿病心肌病中心脏自噬。
Autophagy. 2011 Oct;7(10):1254-5. doi: 10.4161/auto.7.10.16740. Epub 2011 Oct 1.
Zotero 插件