AMP激活的蛋白激酶：一种在心血管系统中具有关键作用的普遍存在的信号通路。
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.
作者信息
Salt Ian P, Hardie D Grahame
机构信息
From the Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Scotland, United Kingdom (I.P.S.); and Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Scotland, United Kingdom (D.G.H.).
出版信息
Circ Res. 2017 May 26;120(11):1825-1841. doi: 10.1161/CIRCRESAHA.117.309633.
Abstract
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inflammatory, and antiatherogenic actions in blood vessels. In this review, we discuss the role of AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK regulates vascular function under physiological and pathophysiological conditions.
摘要
AMP激活的蛋白激酶（AMPK）是细胞和全身能量稳态的关键调节因子，每当细胞能量负荷耗尽时，它就会发挥作用来恢复能量稳态。在过去的20年里，越来越明显的是，AMPK调节其他几种细胞功能，并在心血管组织中具有特定作用，可调节心脏代谢和收缩功能，以及促进血管中的抗收缩、抗炎和抗动脉粥样硬化作用。在这篇综述中，我们讨论了AMPK在心血管系统中的作用，包括改变心脏生理学的AMPK突变的分子基础，以及AMPK在生理和病理生理条件下调节血管功能的 proposed机制。 （注：“proposed”此处可能是“提出的”意思，但原英文中该词拼写有误，正确拼写应为“proposed” ）
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2
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