Tian Buxian, Zhang Yuhong, Li Nan, Liu Xuewen, Dong Jianfeng
Department of Neurology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning Province, China.
Tumour Biol. 2012 Dec;33(6):2273-7. doi: 10.1007/s13277-012-0489-x. Epub 2012 Aug 31.
The expression status of CD74 in breast cancer stem cells and its clinical implications was evaluated in order to lay a foundation for managing breast cancer. Five hundred and eighty breast cancer specimens were enrolled in the study. The relationship between the CD74 protein and clinicopathological parameters as well as prognosis was subsequently determined. In total, 468 (80.69 %) of the 580 breast cases showed CD74-positive expression. After universal analysis, CD74 was observed to be related to lymph node metastasis and triple-negative breast cancer (P = 0.01 and 0.001). Moreover, CD74 expression has a line correlation with lymph node metastasis and triple-negative breast cancer (P = 0.02 and 0.001). Furthermore, periostin was shown to attain a significantly more distant liver metastasis and worse disease-specific survival than those with none or low-expressed CD74 protein (P = 0.001). In the Cox regression test, CD74 protein was detected as an independent prognostic factor (P = 0.001). CD74 is consistently expressed in triple-negative subgroups of breast cancer and might be a new potential marker for triple-negative breast cancer.
为了为乳腺癌的治疗奠定基础，评估了CD74在乳腺癌干细胞中的表达状况及其临床意义。本研究纳入了580例乳腺癌标本。随后确定了CD74蛋白与临床病理参数及预后之间的关系。在580例乳腺癌病例中，共有468例（80.69%）显示CD74阳性表达。综合分析后发现，CD74与淋巴结转移及三阴性乳腺癌相关（P = 0.01和0.001）。此外，CD74表达与淋巴结转移及三阴性乳腺癌呈线性相关（P = 0.02和0.001）。而且，与无CD74蛋白表达或低表达的患者相比，骨膜蛋白显示出更易发生远处肝转移且疾病特异性生存率更差（P = 0.001）。在Cox回归试验中，CD74蛋白被检测为独立的预后因素（P = 0.001）。CD74在乳腺癌的三阴性亚组中持续表达，可能是三阴性乳腺癌的一个新的潜在标志物。
