Bell R S, O'Connor G, Bell D F, Jacob J
Division of Orthopaedic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
J Orthop Res. 1990 Jan;8(1):105-18. doi: 10.1002/jor.1100080114.
Despite the fact that preoperative chemotherapy causes substantial necrosis in the primary osteosarcoma tumor, most authorities recommend resecting these lesions with a wide margin of normal tissue to avoid local recurrence. This study evaluated the effect of systemic chemotherapy (doxorubicin) on tumor growth and histology in the MGH-OGS transplantable murine model and examined whether this drug prevents local recurrence after resection of the tumor with positive microscopic margins. The results indicate that doxorubicin caused prolonged cessation of tumor growth, produced substantial necrosis within the lesion, and decreased the risk of local relapse following marginal surgery. The drug effect was dose-dependent and drug efficacy in preventing local relapse was maximal with administration prior to or at the time of surgery.
尽管术前化疗会导致原发性骨肉瘤肿瘤出现大量坏死，但大多数权威人士仍建议切除这些病变，并保留较宽的正常组织边缘，以避免局部复发。本研究评估了全身化疗（阿霉素）对MGH-OGS可移植小鼠模型中肿瘤生长和组织学的影响，并研究了该药物能否预防在显微镜下切缘阳性的肿瘤切除术后的局部复发。结果表明，阿霉素可使肿瘤生长长期停止，在病变内产生大量坏死，并降低边缘手术术后局部复发的风险。药物效果呈剂量依赖性，在手术前或手术时给药预防局部复发的疗效最佳。
