Bell R S, Roth Y F, Gebhardt M C, Bell D F, Rosenberg A E, Mankin H J, Suit H D
Sarcoma Biology Laboratory, St. Michael's Hospital, Toronto, Ontario, Canada.
Cancer Res. 1988 Oct 1;48(19):5533-8.
The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.
骨肉瘤治疗中化疗和手术的序贯使用是凭经验发展而来的，没有动物模型研究的支持。MGH-OGS小鼠骨肉瘤是一种可移植肿瘤，在组织学、局部侵袭性、转移特征、肿瘤倍体及其对化疗的反应方面与人类疾病相似。我们使用这个肿瘤模型，通过三种不同的实验方案来研究术前、围手术期和术后化疗对肺转移发生的疗效。在每个实验设计中，围手术期化疗在预防全身复发方面显示出显著优势。
