Stawerska Renata, Smyczynska Joanna, Czkwianianc Elzbieta, Pisarek Hanna, Hilczer Maciej, Lewinski Andrzej
Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Polish Mother's Memorial Hospital, Lodz, Poland.
Neuro Endocrinol Lett. 2012;33(4):412-8.
In children with growth hormone deficiency (GHD) and neurosecretory dysfunction (NSD) ghrelin concentrations are significantly higher than in children with idiopathic short stature (ISS), however the correlation between serum ghrelin and growth hormone (GH) is not observed. The aim of the study was to compare ghrelin concentrations with IGF-I/IGFBP3 molar ratio in children with short stature due to different etiology.
Analysis comprised 136 children (58 girls and 78 boys), aged 3.86-16.82 years with short stature (below -2.0 SD); in 21 of them GHD was diagnosed, in 23 - NSD and 92 - ISS. In each child, fasting ghrelin, insulin-like growth factor type I (IGF-I) and its binding protein type 3 (IGFBP-3) concentrations were measured. The results were analysed separately in younger and in older children. Depending on IGF-I/IGFBP-3 molar ratio, children were divided into two (2) groups: with lower IGF-I/IGFBP-3 and with higher IGF-I/IGFBP-3 ratio value.
Both in younger and in the older age groups, ghrelin concentration was significantly higher in children with lower IGF-I/IGFBP-3 ratio than in children with higher IGF-I/IGFBP-3 value (1937.3±1232.4 vs 1365.3±632.1 pg/ml in younger children and 1205.4±548.8 vs 867.4±282.9 pg/ml in older children). The negative correlation between ghrelin and IGF-I/IGFBP-3 ratio was observed in both age groups. Not only children with GHD and NSD, but also as much as 39% out of all children with ISS were qualified into the subgroups with lower IGF-I/IGFBP-3 ratio.
Ghrelin secretion is elevated in children with lower IGF-I/IGFBP-3 ratio. It seems that lower bioactivity of IGF-I is stimulating factor for ghrelin synthesis.
在生长激素缺乏症（GHD）和神经分泌功能障碍（NSD）患儿中，胃饥饿素浓度显著高于特发性矮小症（ISS）患儿，然而未观察到血清胃饥饿素与生长激素（GH）之间的相关性。本研究的目的是比较不同病因导致的矮小症患儿的胃饥饿素浓度与胰岛素样生长因子-I/胰岛素样生长因子结合蛋白-3（IGF-I/IGFBP3）摩尔比。
分析包括136名年龄在3.86 - 16.82岁的矮小症患儿（低于-2.0标准差）（58名女孩和78名男孩）；其中21名被诊断为GHD，23名诊断为NSD，92名诊断为ISS。测量了每个患儿的空腹胃饥饿素、胰岛素样生长因子I（IGF-I）及其结合蛋白3（IGFBP-3）浓度。结果分别在年幼儿童和年长儿童中进行分析。根据IGF-I/IGFBP-3摩尔比，将患儿分为两组：IGF-I/IGFBP-3比值较低组和IGF-I/IGFBP-3比值较高组。
在年幼儿童组和年长儿童组中，IGF-I/IGFBP-3比值较低的患儿的胃饥饿素浓度均显著高于IGF-I/IGFBP-3比值较高的患儿（年幼儿童中为1937.3±1232.4 vs 1365.3±632.1 pg/ml，年长儿童中为1205.4±548.8 vs 867.4±282.9 pg/ml）。在两个年龄组中均观察到胃饥饿素与IGF-I/IGFBP-3比值之间呈负相关。不仅GHD和NSD患儿，而且所有ISS患儿中多达39%被归入IGF-I/IGFBP-3比值较低的亚组。
IGF-I/IGFBP-3比值较低的患儿胃饥饿素分泌升高。似乎IGF-I较低的生物活性是胃饥饿素合成的刺激因素。
