Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.
Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland.
Molecules. 2020 Aug 27;25(17):3912. doi: 10.3390/molecules25173912.
The growth processes in children depend on the proper functioning of some hormones and growth factors. Recently, a positive correlation between ghrelin and TSH (thyroid stimulating hormone) in patients with hyper- and hypothyroidism was proved. Moreover, in hypothyroid rats with high ghrelin concentration, growth hormone (GH) and insulin-like growth factor I (IGF-I) secretion was suppressed. We analyzed these relationships in euthyroid prepubertal children with idiopathic short stature (ISS). The analysis comprised concentration of ghrelin, GH in stimulating tests and during the night, as well as IGF-I, TSH, free thyroxine (FT4) and free triiodothyronine (FT3) in 85 children with ISS (36 girls, 49 boys) aged 9.65 ± 3.02 years (mean ± SD). A strong positive correlation between ghrelin and TSH was confirmed (r = +0.44, < 0.05). A higher ghrelin but lower nocturnal GH and lower IGF-I were observed in children with higher normal TSH concentration than those in children with lower normal TSH. Interestingly, alterations of TSH level were without any impact on FT4 and FT3 concentrations. Summing up, in ISS prepubertal euthyroid children, ghrelin and TSH secretion are closely related. On the other hand, the higher the TSH, the lower the nocturnal GH and IGF-I levels. The contribution of the above findings in deterioration of growth processes requires further studies.
儿童的生长过程取决于某些激素和生长因子的正常功能。最近，证明了甲状腺功能亢进症和甲状腺功能减退症患者的 ghrelin 和 TSH（促甲状腺激素）之间存在正相关。此外，在高 ghrelin 浓度的甲状腺功能减退症大鼠中，生长激素（GH）和胰岛素样生长因子 I（IGF-I）的分泌受到抑制。我们在患有特发性身材矮小症（ISS）的甲状腺功能正常的青春期前儿童中分析了这些关系。分析包括 ghrelin、刺激试验和夜间 GH 以及 IGF-I、TSH、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）的浓度，共纳入 85 名 ISS 儿童（36 名女孩，49 名男孩），年龄 9.65 ± 3.02 岁（均值 ± 标准差）。证实了 ghrelin 和 TSH 之间存在强烈的正相关（r = +0.44， < 0.05）。与 TSH 正常低值组相比，TSH 正常高值组儿童的 ghrelin 水平较高，但夜间 GH 和 IGF-I 水平较低。有趣的是，TSH 水平的改变对 FT4 和 FT3 浓度没有任何影响。总之，在青春期前甲状腺功能正常的 ISS 儿童中，ghrelin 和 TSH 的分泌密切相关。另一方面，TSH 越高，夜间 GH 和 IGF-I 水平越低。这些发现对生长过程恶化的贡献需要进一步研究。
